US Vaccine Exemptions: Growing Pockets of Risk (2026)

A growing concern is emerging across the United States, as more and more families are opting out of childhood vaccinations, leaving a significant portion of the population vulnerable to preventable diseases. This trend, which has been on the rise since the start of the Covid-19 pandemic, is creating larger and riskier gaps in our nation's immunity.

According to recent research published in the medical journal JAMA, exemption rates for vaccines typically required for school attendance have increased in over half of US counties. The primary reason for these exemptions is nonmedical, often based on religious or personal beliefs. In contrast, medical exemptions, such as for immunocompromised individuals or those with severe allergies, have remained stable.

Dr. Jesse Hackell, a pediatrician and lead author of a policy statement from the American Academy of Pediatrics, emphasizes that the science behind immunizations has not changed. "The politics and misinformation surrounding the discussion have shifted, but the facts remain: vaccines are safe, effective, and crucial for reducing disease and saving lives."

The new analysis reveals a concerning trend. The median rate of nonmedical exemptions has risen from an average of 0.6% in 2010-2011 to over 3% in 2023-2024, while medical exemptions have stayed consistent. Nearly 54% of US counties have seen a 1% increase in nonmedical vaccine exemptions, and over 5% have seen a rise of at least 5% in the same period.

The US Centers for Disease Control and Prevention attributes this increase to vaccine hesitancy. A survey conducted by the agency found that while most parents support vaccine requirements for school attendance, those seeking exemptions often cite philosophical or personal belief objections. Difficulty meeting school requirements by deadlines was also a common reason for exemption.

Dr. Nathan Lo, an infectious disease expert and author of the new research, highlights the impact of even small differences in vaccine coverage. "When we look at national or state-level trends, they can be optimistic, but they miss the pockets of communities and counties with low vaccine coverage and high exemption rates. It's these pockets that drive the outbreaks of vaccine-preventable diseases we see across the nation."

The ongoing measles outbreak in Spartanburg County, South Carolina, is a prime example. In 2024, nearly 8% of children had nonmedical exemptions for vaccines required for school attendance, up from 2% in 2014. The outbreak has doubled in size over the past week, with over 400 cases reported and at least 400 others in quarantine. The state health department attributes the spread to holiday activities and low vaccination rates.

"The undervaccinated pockets are interconnected," Lo explains. "When you consider areas with high exemption rates, I think these pockets are growing and becoming more numerous."

The vast majority of measles cases in this outbreak have been among unvaccinated children. Communities with high exemption rates are susceptible to localized epidemics of preventable infectious diseases, but they also pose a risk to others. "If children from these counties with high exemption rates get sick and travel to surrounding areas, even counties with lower exemption rates will see a rise in cases," Hackell says. "There are more people who can spread the diseases to those who are susceptible."

Multiple cases in North Carolina have been linked to family travel to Spartanburg County, and the New Mexico health department has warned of possible measles exposure in Albuquerque from a visitor from South Carolina.

While a handful of states, including California and New York, have successfully removed the option for nonmedical vaccine exemptions, leading to a decrease in overall exemptions, Florida has recently ended all vaccine mandates, including for school attendance. Experts argue that legislative action is the only large-scale intervention proven to change vaccination trends. Increasing vaccination coverage will largely depend on individual conversations between families and their doctors and consistent messaging over time.

"The social norm is to immunize and protect your child and those around them," Hackell emphasizes. "The vast majority of parents choose to vaccinate, and that reflects the scientific consensus."

But here's where it gets controversial: Should personal beliefs and misinformation be allowed to override the collective responsibility to protect our communities? And this is the part most people miss: even small changes in vaccination rates can have a significant impact on disease outbreaks. What do you think? Share your thoughts in the comments!

US Vaccine Exemptions: Growing Pockets of Risk (2026)
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